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Redefining the Multiple Sclerosis Severity Score (MSSS): The effect of sex and onset phenotype

Zhou, Y. and Claflin, S.B. and Stankovich, J. and van der Mei, I. and Simpson, Jr and Roxburgh, R.H. and Kalincik, T. and Blizzard, L. and Lugaresi, A. and Alroughani, R. and Sajedi, S.A. and Butzkueven, H. and Pucci, E. and Spitaleri, D.L.A. and Granella, F. and Cristiano, E. and Yamout, B. and Hughes, S. and Gouider, R. and Sánchez Menoyo, J.L. and Olascoaga, J. and McGuigan, C. and Shaw, C. and Kermode, A.G. and Kasa, K. and Al-Harbi, T. and Altintas, A. and Laureys, G. and Fragoso, Y. and Hardy, T.A. and Csepany, T. and Sirbu, C.-A. and Decoo, D. and Sas, A. and Alvarez-Cermeño, J.C. and Kotkata, K. and Millán-Pascual, J. and Taylor, B.V. (2019) Redefining the Multiple Sclerosis Severity Score (MSSS): The effect of sex and onset phenotype. Multiple Sclerosis Journal.

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Abstract

Background: The Multiple Sclerosis Severity Score (MSSS) is a widely used measure of the disability progression rate. However, the global MSSS may not be the best basis for comparison between all patient groups. Objective: We evaluated sex-specific and onset phenotype�specific MSSS matrices to determine if they were more effective than the global MSSS as a basis for comparison within these subsets. Methods: Using a large international dataset of multiple sclerosis (MS) patient records and the original MSSS algorithm, we constructed global, sex-specific and onset phenotype�specific MSSS matrices. We compared matrices using permutation analysis. Results: Our final dataset included 30,203 MS cases, with 28.9 males and 6.5 progressive-onset cases. Our global MSSS matrix did not differ from previously published data (p > 0.05). The progressive-onset-specific matrix differed significantly from the relapsing-onset-specific matrix (p < 0.001), with lower MSSS attributed to cases with the same Expanded Disability Status Score (EDSS) and disease duration. When evaluated with a simulation, using an onset-specific MSSS improved statistical power in mixed cohorts. There were no significant differences by sex. Conclusion: The differences in the disability accrual rate between progressive- and relapsing-onset MS have a significant effect on MSSS. An onset-specific MSSS should be used when comparing the rate of disability progression among progressive-onset cases and for mixed cohorts. © The Author(s), 2019.

Item Type: Article
Additional Information: cited By 0
Subjects: سیستم عصبی WL
بیماریهای تغذیه ومتابولیکی WD
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Dec 2019 10:33
Last Modified: 18 Dec 2019 10:33
URI: http://eprints.goums.ac.ir/id/eprint/10476

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