Golestan University of Medical Sciences Repository

Distinct genetic variation and heterogeneity of the Iranian population

Mehrjoo, Z. and Fattahi, Z. and Beheshtian, M. and Mohseni, M. and Poustchi, H. and Ardalani, F. and Jalalvand, K. and Arzhangi, S. and Mohammadi, Z. and Khoshbakht, S. and Najafi, F. and Nikuei, P. and Haddadi, M. and Zohrehvand, E. and Oladnabi, M. and Mohammadzadeh, A. and Jafari, M.H. and Akhtarkhavari, T. and Gooshki, E.S. and Haghdoost, A. and Najafipour, R. and Niestroj, L.-M. and Helwing, B. and Gossmann, Y. and Toliat, M.R. and Malekzadeh, R. and Nürnberg, P. and Kahrizi, K. and Najmabadi, H. and Nothnagel, M. (2019) Distinct genetic variation and heterogeneity of the Iranian population. PLoS Genetics, 15 (9).

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Iran, despite its size, geographic location and past cultural influence, has largely been a blind spot for human population genetic studies. With only sparse genetic information on the Iranian population available, we pursued its genome-wide and geographic characterization based on 1021 samples from eleven ethnic groups. We show that Iranians, while close to neighboring populations, present distinct genetic variation consistent with long-standing genetic continuity, harbor high heterogeneity and different levels of consanguinity, fall apart into a cluster of similar groups and several admixed ones and have experienced numerous language adoption events in the past. Our findings render Iran an important source for human genetic variation in Western and Central Asia, will guide adequate study sampling and assist the interpretation of putative disease-implicated genetic variation. Given Iran�s internal genetic heterogeneity, future studies will have to consider ethnic affiliations and possible admixture. © 2019 Mehrjoo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: adult; Article; Central Asian; consanguinity; controlled study; female; genetic heterogeneity; genetic variation; human; Iran; Iranian people; language; male; neighborhood; population; West Asian
Subjects: آسیب شناسی QZ
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Dec 2019 10:30
Last Modified: 18 Dec 2019 10:30
URI: http://eprints.goums.ac.ir/id/eprint/10475

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