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Anti-Inflammatory and Immunomodulatory Effects of Barberry (Berberis vulgaris) and Its Main Compounds

Kalmarzi, R.N. and Naleini, S.N. and Ashtary-Larky, D. and Peluso, I. and Jouybari, L. and Rafi, A. and Ghorat, F. and Heidari, N. and Sharifian, F. and Mardaneh, J. and Aiello, P. and Helbi, S. and Kooti, W. (2019) Anti-Inflammatory and Immunomodulatory Effects of Barberry (Berberis vulgaris) and Its Main Compounds. Oxidative Medicine and Cellular Longevity, 2019.

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Abstract

Berberis vulgaris is a well-known herb in Iran that is widely used as a medicinal plant and a food additive. The aim of this study was to investigate the anti-inflammatory and immunomodulatory effects of Barberry and its main compounds. This narrative review was conducted by searching keywords such as B. vulgaris, Barberry, immunomodulatory, anti-inflammatory, medicinal herbs, plants, and extract, separately or combined in various databases, such as Web of Sciences, PubMed, and Scopus. According to the inclusion and exclusion criteria, just English language articles, which reported effective whole plants or herbal compounds, were included. 21 articles were reviewed in this study. In the in vivo models (mice, rats, and human cells) and in the in vitro models (some organ cells such as the spleen, kidney, blood, and brain), B. vulgaris and its main components showed anti-inflammatory effects in both models. The main mechanisms were the shift of cell immune response to Th2, T reg induction, inhibition of inflammatory cytokines (IL-1, TNF, and IFN-γ), and stimulation of IL-4 and IL-10. The induction of apoptosis in APCs and other effector cells was another important mechanism. © 2019 Rasool Nasiri Kalmarzi et al.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Cell death; Mammals, Anti-inflammatories; Anti-inflammatory effects; English languages; Immunomodulatory; Immunomodulatory effects; Inclusion and exclusions; Inflammatory cytokines; Medicinal plants, Plant extracts
Subjects: فارماکولوژی QV
> دانشکده داروسازی > فارماکولوژی QV

میکروب شناسی وایمنی شناسی QW
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Dec 2019 10:07
Last Modified: 18 Dec 2019 10:07
URI: http://eprints.goums.ac.ir/id/eprint/10473

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