Golestan University of Medical Sciences Repository

Association of lipid markers with coronary heart disease and stroke mortality: A 15-year follow-up study

Pahlavanzade, B. and Zayeri, F. and Baghfalaki, T. and Mozafari, O. and Khalili, D. and Azizi, F. and Abadi, A. (2019) Association of lipid markers with coronary heart disease and stroke mortality: A 15-year follow-up study. Iranian Journal of Basic Medical Sciences, 22 (11). pp. 1325-1330.

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Abstract

Objective(s): It has been proposed that lipid markers may predict cardiovascular events; however, their effect may vary depending on the type of cardiovascular disease. The purpose of this study was to investigate the effects of lipid markers on death from coronary heart disease (CHD) and stroke in competing risks setting. Materials and Methods: Participants included 2502 women and 2020 men, age 40 years or older from Tehran Lipid and Glucose Study. The association between total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) with hazard and cumulative incidence of CHD and stroke was investigated using cause-specific hazard and sub-distribution hazard models. Statistical analyses were performed using "risk regression" and "cmprsk" package in R 3.3.2. Results: One standard deviation (SD) increase in TC and LDL-C increased the hazard of CHD death by 1.42 (CI=1.07,1.89) and 1.41 (CI=1.04,1.93), respectively. 1-SD increase in TG increased the cumulative incidence of CHD death increased by 1.94 (CI=1.02,3.75) in women. Other risk factors were not associated with the hazard and cumulative incidence of CHD in women, men and the total sample. In addition, none of lipids had a significant effect on the hazard and cumulative incidence of stroke in men, women and the total sample. Conclusion: The associations of lipid components on CHD death were modified by gender. TC, LDL-C and TG were independent predictors of CHD mortality in women. Furthermore, death due to stroke changes the association of lipid markers with CHD mortality. © 2019 Mashhad University of Medical Sciences. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: antilipemic agent; biochemical marker; cholesterol; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol, adult; age; anthropometry; Article; blood pressure; body mass; cerebrovascular accident; cholesterol blood level; clinical outcome; cohort analysis; diabetes mellitus; disease association; female; follow up; glucose blood level; hazard ratio; high density lipoprotein cholesterol level; human; incidence; ischemic heart disease; lipid fingerprinting; lipid lowering medication; low density lipoprotein cholesterol level; major clinical study; male; mortality rate; prevalence; risk factor; smoking; systolic blood pressure; triacylglycerol blood level
Subjects: سیستم غدد WK
سیستم قلب وعروق WG
QU بیوشیمی
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 18 Dec 2019 11:07
Last Modified: 18 Dec 2019 11:07
URI: http://eprints.goums.ac.ir/id/eprint/10459

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