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Association of MTHFR C677T Polymorphism with Preeclampsia in North East of Iran (Khorasan Province)

Azimi-Nezhad, M. and Teymoori, A. and Salmaninejad, A. and Ebrahimzadeh-Vesal, R. (2019) Association of MTHFR C677T Polymorphism with Preeclampsia in North East of Iran (Khorasan Province). Fetal and Pediatric Pathology.

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Abstract

Background: Preeclampsia (PE) is one of the main causes of fetal and maternal mortality. The analysis of candidate gene polymorphisms can improve our understanding of the mechanisms underlying pathogenesis of PE. Present study is aimed at investigating the association between MTRR c.66A > G, MTHFR c.677C > T, MTHFR c.1298A > C, and MTR c.2756A > G polymorphisms and PE in Iranian women. Methods: About 117 women with history of PE and 103 healthy women with a pregnancy not complicated by PE were selected. The genomic DNA was extracted from peripheral blood. Single-nucleotide polymorphisms were genotyped using Real-Time PCR. Results: There was a significant difference between MTHFR c.677C > T polymorphism with PE (p = 0.045). The frequency of C/T heterozygous genotypes were (58 vs. 36) in the case and control groups, respectively. There were no statistically significant differences between other genetic polymorphisms. Conclusions: The results indicated that the MTHFR c.677C > T polymorphism may be associated with development of PE in Iranian women. © 2019, © 2019 Taylor & Francis Group, LLC.

Item Type: Article
Additional Information: cited By 0
Subjects: مامایی WQ
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 16 Dec 2019 11:16
Last Modified: 16 Dec 2019 11:16
URI: http://eprints.goums.ac.ir/id/eprint/10433

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