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Factors predicting the outcome of intravenous thrombolysis in stroke patients before rt-PA administration

Mehrpour, M. and Afrakhte, M. and Shojaei, S.F. and Sohrabi, A. and Ashayeri, R. and Esmaeili, S. and Bahadori, M. (2019) Factors predicting the outcome of intravenous thrombolysis in stroke patients before rt-PA administration. Caspian Journal of Internal Medicine, 10 (4). pp. 424-430.

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Abstract

Background: To determine whether it is possible to predict intravenous thrombolytic therapy (IVT) outcome after 3 months in acute ischemic stroke patients who are candidate to receive recombinant tissue plasminogen activator (rt-PA), before rt-PA administration based on their risk factors and some available laboratory results. Methods: We enrolled 118 ischemic stroke patients who were treated with standard dose of Alteplase in our hospital. Baseline characteristics, door-to-needle time (DTN), onset-to-treatment time (OTT), the National Institute Health Stroke Scale (NIHSS), systolic and diastolic blood pressure on admission, history of diabetes, hypertension, dyslipidemia, coronary artery disease (CAD), previous ischemic stroke, atrial fibrillation (AF), laboratory results were retrospectively collected. The modified Rankin Scale (MRS) was recorded after 3 months of admission and patients were divided into good (MRS 2) and poor (MRS>2) outcome groups. Chi-square test and t-test were used for categorical and continuous variables, respectively. Predictors for outcome after 3 months were studied by multivariable logistic regression. Results: Good outcome was seen in 60 (51) patients and poor outcome was seen in 58 (49) patients. Significant predictors for outcome at 3 months according to multivariable regression analysis were NIHSS score (odds ratio OR, 0.61; 95% confidence interval CI, 0.498-0.750; p<0.001), SBP (OR, 0.95; 95% CI, 0.925-0.991; P=0.01), AF (OR, 0.09; 95% CI, 0.013- 0.708; P=0.02), CAD (OR, 17.08; 95% CI, 0.013-0.708; p=0.003). Conclusion: Higher NIHSS score, higher SBP on admission, AF and history of CAD could be the independent predictors of outcome after IVT in acute ischemic stroke patients. © 2019 Babol University of Medical Sciences. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: alteplase, adult; aged; Article; atrial fibrillation; brain ischemia; coronary artery disease; diabetes mellitus; diastolic blood pressure; dyslipidemia; female; fibrinolytic therapy; human; hypertension; major clinical study; male; National Institutes of Health Stroke Scale; predictive value; Rankin scale; retrospective study; smoking; stroke patient; systolic blood pressure; treatment outcome
Subjects: سیستم عصبی WL
سیستم قلب وعروق WG
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 17 Dec 2019 07:01
Last Modified: 17 Dec 2019 07:01
URI: http://eprints.goums.ac.ir/id/eprint/10405

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