Golestan University of Medical Sciences Repository

Association of perforin and granzyme-B levels with hyperandrogenism in polycystic ovary syndrome: A case-control study

Zarei, E. and Mohajery, H. and Aliakbari, F. and Zadeh, F.M. and Veghari, G. and Mansourian, A. (2019) Association of perforin and granzyme-B levels with hyperandrogenism in polycystic ovary syndrome: A case-control study. Pakistan Journal of Biological Sciences, 22 (8). pp. 393-399.

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Abstract

Background and Objective: Polycystic ovary syndrome (PCOS) is shown to be associated with hyperandrogenemia and has some features such as cytotoxic T-cells activation and release of perforin and granzyme-B. Present work was aimed to investigate the relation of perforin and granzyme-B to androgenic state in PCOS. Materials and Methods: Forty three PCOS and 40 control women were recruited. After recording demographic data, sex hormone status and cardiovascular disease (CVD) risk factors were evaluated. Perforin and granzyme-B levels were measured using sandwich ELISA kits. Results: Sex hormone binding globulin (SHBG) levels were lower in patients. Luteinizing hormone (LH), free testosterone (FT), dehydroepiandrosterone sulfate (DHEA-S), free androgen index (FAI), perforin and granzyme-B values were higher in PCOS group. Perforin and granzyme-B were positively correlated with FT and FAI and with each other in PCOS group. In patients, granzyme-B and perforin were related with FT and FAI, respectively. Conclusion: The results of present study together with evidences about the release of pro-inflammatory cytokines in insulin resistance, CVD and PCOS suggest that perforin/granzyme-B may be involved in interactions of sex hormones system in PCOS patients. © 2019 Elham Zarei et al.

Item Type: Article
Additional Information: cited By 0
Subjects: بیماریهای زنان WP
سیستم غدد WK
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 17 Dec 2019 06:54
Last Modified: 17 Dec 2019 06:54
URI: http://eprints.goums.ac.ir/id/eprint/10403

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