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Environmental determinants of behavioural responses to short-term stress in rats: Evidence for inhibitory effect of ambient landmarks

Faraji, J. and Singh, S. and Soltanpour, N. and Sutherland, R.J. and Metz, G.A.S. (2019) Environmental determinants of behavioural responses to short-term stress in rats: Evidence for inhibitory effect of ambient landmarks. Behavioural Brain Research.

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Abstract

Behavioural responses to stress occur in an environment-dependent manner. Complex environments require flexible behavioural coping strategies and chronic stress usually generates psychomotor inhibition. Here, we examine if short-term stress also exerts an inhibitory effect on novelty-seeking, exploratory behaviours. Rats underwent acute restraint stress or were left undisturbed, and their neuroendocrine and behavioural responses were assessed at short- and long-term time points. Animals were individually tested in the open field task (OFT) and the corridor field task (CFT) with and without a central object for free exploration and novelty seeking behaviour. Stress-related psychomotor alterations were measured by path speed, path length, number of stops and thigmotaxis in both tasks. Short-term stress activated the hypothalamic-pituitary-adrenal axis causing elevated plasma corticosterone levels. Stress also impacted psychomotor functions in terms of motivational changes (higher speed and longer path) only in the central-object variations of the OFT and CFT. Moreover, stress-induced emotional alterations were manifested by a higher number of stops and thigmotactic behaviour only in the central-object condition. These findings suggest that environmental landmarks determine the type and direction of exploratory behaviour under transient stress. © 2019 Elsevier B.V.

Item Type: Article
Additional Information: cited By 0
Subjects: روانپزشکی WM
QS آناتومی انسان
QTفیزیولوژی
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 17 Dec 2019 08:50
Last Modified: 17 Dec 2019 08:50
URI: http://eprints.goums.ac.ir/id/eprint/10398

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