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Comparison effect of tranexamic acid (TA) and tranexamic acid combined with vitamin C (TXC) on drainage volume and atrial fibrillation arrhythmia in patients undergoing cardiac bypass surgery: Randomized clinical trial

Ghorbaninezhad, K. and Bakhsha, F. and Yousefi, Z. and Halakou, S. and Mehrbakhsh, Z. (2019) Comparison effect of tranexamic acid (TA) and tranexamic acid combined with vitamin C (TXC) on drainage volume and atrial fibrillation arrhythmia in patients undergoing cardiac bypass surgery: Randomized clinical trial. Anesthesiology and Pain Medicine, 9 (5).

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Abstract

Background: Tranexamic acid and vitamin C are potent antifibrinolytic and oxidative stress agents that reduce blood loss and transfusion blood in cardiopulmonary bypass (CPB). Objectives: The aim of this study was to evaluate the efficacy of tranexamic acid (TA) and tranexamic acid combined with vitamin C (TXC) on drainage volume (blood loss) and atrial fibrillation (AF) in patients undergoing cardiac bypass surgery in Gorgan, Shafa hospital, Iran. Methods: This study is a double-blind randomized clinical trial. A sample size of 120 candidates of cardiac bypass surgery were included in this prospective study. Patients were randomly assigned to treatments in two groups. In both groups, 50 mg/kg tranexamic acid was administered intravenously directly before sternotomy: group A (N = 58) patients received tranexamic acid (TA) only and group B (N = 62) tranexamic acid with vitamin C (TXC) half an hour before surgery and 2 g vitamin C with 100 mL 0.9 saline were injected. Subsequently, during 4 days after surgery, 1000 mg of vitamin C and 100 cc 0.9 saline was infused every day. Intraoperative and postoperative blood loss (volume of blood in the drain) and atrial fibrillation complications were recorded for 24 hours after the operation. Results: The patients who received vitamin C had less bleeding during operation and in the early hours post-operation. Patients in (TA) group had mean drainage of 34.41 milliliter more than patients in (TXC) group (P < 0.001). Chi-square test showed that arrhythmia (AF) condition was the same in the two groups during 14 times of study (four times during operation and ten times up to 24 hours after the operation), and AF arrhythmia in the two groups was less than 5. Conclusions: In this study tranexamic acid with vitamin C have a positive effect on the amount of drainage (blood loss) and there was no significant difference in the incidence of AF between two groups. © 2019, Author(s).

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: ascorbic acid; tranexamic acid; tranexip, adult; arterial oxygen saturation; Article; atrial fibrillation; blood pressure monitoring; body mass; controlled study; double blind procedure; drug dose reduction; electrolyte blood level; extracorporeal circulation; female; glucose blood level; heart rate; heart surgery; hematocrit; hemodynamic parameters; hemoglobin blood level; human; major clinical study; male; mean arterial pressure; middle aged; partial thromboplastin time; postoperative hemorrhage; prospective study; randomized controlled trial; sternotomy; urine volume
Subjects: سیستم قلب وعروق WG
QU بیوشیمی
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Dec 2019 11:49
Last Modified: 15 Dec 2019 11:49
URI: http://eprints.goums.ac.ir/id/eprint/10394

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