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Therapeutic bacteria to combat cancer; current advances, challenges, and opportunities

Sedighi, M. and Zahedi Bialvaei, A. and Hamblin, M.R. and Ohadi, E. and Asadi, A. and Halajzadeh, M. and Lohrasbi, V. and Mohammadzadeh, N. and Amiriani, T. and Krutova, M. and Amini, A. and Kouhsari, E. (2019) Therapeutic bacteria to combat cancer; current advances, challenges, and opportunities. Cancer Medicine, 8 (6). pp. 3167-3181.

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Successful treatment of cancer remains a challenge, due to the unique pathophysiology of solid tumors, and the predictable emergence of resistance. Traditional methods for cancer therapy including radiotherapy, chemotherapy, and immunotherapy all have their own limitations. A novel approach is bacteriotherapy, either used alone, or in combination with conventional methods, has shown a positive effect on regression of tumors and inhibition of metastasis. Bacteria-assisted tumor-targeted therapy used as therapeutic/gene/drug delivery vehicles has great promise in the treatment of tumors. The use of bacteria only, or in combination with conventional methods was found to be effective in some experimental models of cancer (tumor regression and increased survival rate). In this article, we reviewed the major advantages, challenges, and prospective directions for combinations of bacteria with conventional methods for tumor therapy. © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: antineoplastic agent; bacterial toxin; bacterial vaccine; BCG vaccine; botulinum toxin; Clostridium perfringens enterotoxin; CpG oligodeoxynucleotide; cytolysin; cytolysin A; cytosine deaminase; cytotoxic necrotizing factor 1; diphtheria toxin; docetaxel; doxorubicin; fluorouracil; folinic acid; fusion protein; interleukin 4 Pseudomonas exotoxin fusion protein; Listeria monocytogenes vaccine; milataxel; nitroreductase; probiotic agent; RecA protein; salmonellosis vaccine; survivin; taltobulin; tumor necrosis factor; unclassified drug; unindexed drug; vinorelbine tartrate; VSL3, alopecia; antineoplastic activity; astrocytoma; bacterial spore; bacteriotherapy; Bifidobacterium; blood toxicity; brachytherapy; breast cancer; cancer immunotherapy; cancer radiotherapy; cardiotoxicity; Caulobacter; Clostridia; Clostridium acetobutylicum; Clostridium novyi; Clostridium sporogenes; colon cancer; colorectal cancer; continuous infusion; diarrhea; Ehrlich ascites tumor; Escherichia; external beam radiotherapy; fibrosarcoma; gastrointestinal toxicity; gene therapy; glioblastoma; human; Lactobacillus; Listeria; malignant neoplasm; melanoma; mucosa inflammation; neck tumor; nonhuman; priority journal; Proteus; Pseudomonas; Review; Salmonella; single drug dose; skin toxicity; Streptococcus; Streptococcus pyogenes; systemic disease; thermotherapy; transgenic microorganism; tumor regression; uterine cervix cancer
Subjects: پزشکی عملیWB
آسیب شناسی QZ
میکروب شناسی وایمنی شناسی QW
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 15 Dec 2019 10:07
Last Modified: 15 Dec 2019 10:07
URI: http://eprints.goums.ac.ir/id/eprint/10378

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