Golestan University of Medical Sciences Repository

Association study of M235T and A-6G polymorphisms in angiotensinogen gene with risk of developing preeclampsia in Iranian population

Alaee, E. and Mirahmadi, M. and Ghasemi, M. and Kashani, E. and Attar, M. and Shahbazi, M. (2019) Association study of M235T and A-6G polymorphisms in angiotensinogen gene with risk of developing preeclampsia in Iranian population. Annals of Human Genetics, 83 (6). pp. 418-425.

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Abstract

Objective: Preeclampsia (PE) is a life-threatening complication of pregnancy that accounts for 12 of all maternal deaths worldwide. The aim of this study is to investigate the relationships between the polymorphisms of angiotensinogen (AGT) gene and preeclampsia. Material and methods: In this study, 240 unrelated preeclampsia patients and 178 normotensive women were examined. Genomic DNA was extracted then we assessed M235T(C/T) and A-6G polymorphisms of the AGT gene. Genotyping of M235T and A-6G polymorphisms were performed using SSP-PCR and MS-PCR, respectively. Results: A significant protective association was observed between A-6G G allele, A-6G A/G heterozygote genotype (OR = 0.6, p = 0.007 and OR = 0.6, p = 0.04) against PE. Furthermore, it was shown that two copies of A-6G A allele would increase PE risk (OR: 0.62, p = 0.04). Our results did not show a significant association for M235T polymorphism and PE. However, the combinations of A-6G A/A genotype and M235T T/C genotype (OR = 0.4, p = 0.02) and also A-6G A/G genotype and M235T T/C genotype (OR = 0.5, p = 0.04) in controls represented a significant protective association against PE. Conclusion: According to the existence of significant correlation between two candidate polymorphisms, A-6G and M235T polymorphisms, with PE disease in our study, they may be considered as valuable factors in susceptibility to PE disease in Iranian women. © 2019 John Wiley & Sons Ltd/University College London

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: angiotensinogen; genomic DNA, adult; Article; controlled study; DNA extraction; female; gene frequency; genetic association; genetic polymorphism; genetic risk; genotype; human; Iranian people; major clinical study; preeclampsia; priority journal; sequence specific primer polymerase chain reaction
Subjects: آسیب شناسی QZ
مامایی WQ
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 10 Dec 2019 08:33
Last Modified: 10 Dec 2019 08:33
URI: http://eprints.goums.ac.ir/id/eprint/10361

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