Golestan University of Medical Sciences Repository

Comparing anthropometric indicators of visceral and general adiposity as determinants of overall and cardiovascular mortality

Nalini, M. and Sharafkhah, M. and Poustchi, H. and Sepanlou, S.G. and Pourshams, A. and Radmard, A.R. and Khoshnia, M. and Gharavi, A. and Dawsey, S.M. and Abnet, C.C. and Boffetta, P. and Brennan, P. and Sotoudeh, M. and Nikmanesh, A. and Merat, S. and Etemadi, A. and Shakeri, R. and Malekzadeh, R. and Kamangar, F. (2019) Comparing anthropometric indicators of visceral and general adiposity as determinants of overall and cardiovascular mortality. Archives of Iranian Medicine, 22 (6). pp. 301-309.

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Abstract

Background: It is unclear which anthropometric obesity indicator best predicts adverse health outcomes. This study aimed to investigate the association of body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), waist-to-hip ratio (WHR), and hip-adjusted WC with all-cause and cardiovascular mortality. Methods: 50 045 people aged 40-75 (58 women, median BMI: 26.3 kg /m2) participated in the population-based Golestan Cohort Study. We used Cox regression to estimate hazard ratios (HRs) and 95 confidence intervals (95 CI) for the association of obesity indicators with mortality. We also examined the association of these indicators with intermediate outcomes, including hypertension, blood glucose, dyslipidemia, carotid atherosclerosis, nonalcoholic fatty liver, and visceral abdominal fat. Results: After a median follow-up of 10.9 years (success rate: 99.1), 6651 deaths (2778 cardiovascular) occurred. Comparing 5th to the 1st quintile, HRs (95 CIs) for all-cause and cardiovascular mortality were 1.12 (1.02-1.22) and 1.59 (1.39-1.83) for BMI, 1.16 (1.07-1.27) and 1.66 (1.44-1.90) for WC, 1.28 (1.17-1.40) and 1.88 (1.63-2.18) for WHtR, 1.44 (1.32-1.58) and 2.04 (1.76-2.36) for WHR, and 1.84 (1.62-2.09) and 2.72 (2.23-3.32) for hip-adjusted WC, respectively. Hip-adjusted WC had the strongest associations with the intermediate outcomes. Conclusion: Indicators of visceral adiposity (e.g., hip-adjusted WC) were much stronger predictors of overall and cardiovascular mortality than were indicators of general adiposity (e.g., BMI). The full-strength effect of visceral adiposity becomes apparent only when both WC, as a risk factor, and hip circumference, as a protective factor, are individually and simultaneously taken into consideration. © 2019 The Author(s).

Item Type: Article
Additional Information: cited By 0
Subjects: سیستم قلب وعروق WG
آسیب شناسی QZ
بهداشت عمومی WA > آمار حیاتیWA
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 22 Sep 2019 11:42
Last Modified: 22 Sep 2019 11:42
URI: http://eprints.goums.ac.ir/id/eprint/10336

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