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Gestational diabetes mellitus in mothers and long term cardiovascular disease in both parents: Results of over a decade follow-up of the Iranian population

Kabootari, M. and Hasheminia, M. and Guity, K. and Ramezankhani, A. and Azizi, F. and Hadaegh, F. (2019) Gestational diabetes mellitus in mothers and long term cardiovascular disease in both parents: Results of over a decade follow-up of the Iranian population. Atherosclerosis, 288. pp. 94-100.

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Abstract

Background and aims: We aimed at evaluating whether the presence of gestational diabetes mellitus (GDM) in mothers is associated with increased risk of incident cardiovascular disease (CVD) in both mothers and fathers. Methods: In this population-based study, 4308 Iranian women, aged 18�64 years, with at least 1 live-birth delivery, and free of CVD at baseline, were followed. Corresponding spouses were identified in 2547 cases. The association between history of GDM and incident CVD was assessed using multivariate Cox's proportional hazard in 3 models: model 1, unadjusted; model 2, adjusted for age, body mass index, smoking (for men), maternal parity, miscarriage, physical activity, hypertension and hypercholesterolemia, and model 3, further adjusted for diabetes mellitus. Results: After a median follow-up of 14.1 years, 314 mothers and 424 fathers experienced CVD. Women with history of GDM had an adjusted hazard ratio (HR), 95 CI of 1.85 (1.38�2.48) and 1.29 (0.96�1.75) for CVD in models 1 and 2, respectively. Furthermore, an independent association with CVD was observed in fathers with an adjusted HR of 1.35 (1.02�1.79) in the confounder adjusted model and even after further controlling for diabetes 1.36 (1.03�1.80). Moreover, all traditional risk factors, excluding BMI, showed an independent risk for CVD in both genders. Conclusions: Women with prior GDM showed an increased risk of CVD that was not independent of important CVD risk factors. However, among men, spousal history of GDM was an independent risk factor for incident CVD, even after considering important traditional risk factors, including diabetes. © 2019 Elsevier B.V.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: adult; Article; body mass; cardiovascular disease; diastolic blood pressure; female; follow up; human; hypercholesterolemia; Iranian (citizen); live birth; longitudinal study; major clinical study; male; maternal hypertension; mother; parent; parity; physical activity; population research; pregnancy diabetes mellitus; priority journal; prospective study; smoking; spontaneous abortion; spouse; systolic blood pressure
Subjects: سیستم غدد WK
سیستم قلب وعروق WG
مامایی WQ
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 22 Sep 2019 07:59
Last Modified: 22 Sep 2019 07:59
URI: http://eprints.goums.ac.ir/id/eprint/10284

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