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Scavenger receptor Class B type I as a potential risk stratification biomarker and therapeutic target in cardiovascular disease

Sahebi, R. and Hassanian, S.M. and Ghayour-Mobarhan, M. and Farrokhi, E. and Rezayi, M. and Samadi, S. and Bahramian, S. and Ferns, G.A. and Avan, A. (2019) Scavenger receptor Class B type I as a potential risk stratification biomarker and therapeutic target in cardiovascular disease. Journal of Cellular Physiology, 234 (10). pp. 16925-16932.

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Abstract

Cardiovascular disease (CVD) is the leading cause of mortality globally. There are few useful markers available for CVD risk stratification that has proven clinical utility. Scavenger receptor B type I (SR-BI) is a cell surface protein that plays a major role in cholesterol homeostasis through its interaction with high-density lipoprotein-cholesterol (HDL-C) esters (CE). HDL delivers CE to the liver through selective uptake by the SR-BI. SR-BI also regulates the inflammatory response. It has been shown that SR-BI overexpression has beneficial, protective effects in atherogenesis, and there is considerable interest in developing antiatherogenic strategies that involve SR-BI-mediated increases in reverse cholesterol transport through HDL and/or low-density lipoprotein. Further investigations are essential to explore the clinical utility of this approach. Moreover, there is growing evidence showing associations between genetic variants with modulation of SR-BI function that may, thereby, increase CVD risk. The aim of the current review was to provide an overview of the possible molecular mechanisms by which SR-BI may affect CVD risk, and the clinical implications of this, with particular emphasis on preclinical studies on genetic changes of SR-BI and CVD risk. © 2019 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 0
Subjects: فارماکولوژی QV > بیوتکنولوژی دارویی
> دانشکده داروسازی > فارماکولوژی QV > بیوتکنولوژی دارویی

سیستم قلب وعروق WG
QU بیوشیمی
فارماکولوژی QV
> دانشکده داروسازی > فارماکولوژی QV
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 22 Sep 2019 06:40
Last Modified: 22 Sep 2019 06:40
URI: http://eprints.goums.ac.ir/id/eprint/10273

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