Golestan University of Medical Sciences Repository

Effect of single-dose injection of vitamin D on immune cytokines in ulcerative colitis patients: a randomized placebo-controlled trial

Sharifi, A. and Vahedi, H. and Nedjat, S. and Rafiei, H. and Hosseinzadeh-Attar, M.J. (2019) Effect of single-dose injection of vitamin D on immune cytokines in ulcerative colitis patients: a randomized placebo-controlled trial. APMIS, 127 (10). pp. 681-687.

Full text not available from this repository.

Abstract

Ulcerative colitis (UC) is a chronic recurrent inflammation of the colon. It has been proposed that the UC pathogenesis may be related to vitamin D deficiency and/or vitamin D administration in UC patients may have an ameliorating effect on the intestinal inflammation. The aim of this study was to assess the effect of vitamin D on the serum levels of immune cytokines in UC patients. In this double-blind randomized controlled trial, 90 mild-to-moderate UC patients were assigned to get either a single muscular injection of 7.5 mg vitamin D3 or 1 mL normal saline as placebo. Three months later serum levels of IL-4, IL-10, IL-12p70, IFN-γ, and TNF-α were measured. Two group variables were compared using independent t-test and analysis of covariance (ANCOVA). There was a significant increase in vitamin D only in the vitamin D group. Compared to placebo, vitamin D had significant decreasing effects on serum TNF-α, IFN-γ, and IL12p70 levels, but it had no significant effect on serum levels of IL4 and IL10. Vitamin D seems to inhibit Th1 immune responses and have no effect on Th2 responses. The findings of this study support several in vitro studies, which suggest a therapeutic immunomodulatory potential of vitamin D. © 2019 APMIS. Published by John Wiley & Sons Ltd

Item Type: Article
Additional Information: cited By 0
Subjects: فارماکولوژی QV > بیوتکنولوژی دارویی
> دانشکده داروسازی > فارماکولوژی QV > بیوتکنولوژی دارویی

QU بیوشیمی
میکروب شناسی وایمنی شناسی QW
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 22 Sep 2019 06:34
Last Modified: 22 Sep 2019 06:34
URI: http://eprints.goums.ac.ir/id/eprint/10271

Actions (login required)

View Item View Item