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Investigating the best strategy to diminish the toxicity and enhance the antibacterial activity of graphene oxide by chitosan addition

Joz Majidi, H. and Babaei, A. and Arab Bafrani, Z. and Shahrampour, D. and Zabihi, E. and Jafari, S.M. (2019) Investigating the best strategy to diminish the toxicity and enhance the antibacterial activity of graphene oxide by chitosan addition. Carbohydrate Polymers, 225.

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Abstract

The main objective of this work was to find a way to increase the bio-applicability of graphene oxide (GO) nanoparticles. In this way, various kinds of graphene oxide-chitosan (GO-CS) nano-hybrids were synthesized through attachment of different kinds of chitosan (CS) structures with GO. Subsequently, they were assessed in terms of structural characterization, antibacterial activity and cytotoxicity to obtain a hybrid structure representing the highest bactericidal and biocompatibility performance. Our results revealed that the single-layer GO and also three different kinds of GO-CS nano-hybrid structures (pristine powder, spherical and nano-fibrilar network structures) were successfully synthesized. Antibacterial activity results indicated superior antibacterial activity of nano-hybrids compared to the pure GO. In addition, it was observed that the attachment of CS to GO interestingly reduced the cytotoxicity effect of GO and even caused cell proliferation in some samples. Furthermore, the antibacterial and bio-safety properties of different hybrids were compared and suggestive mechanisms for their particular performances were proposed. © 2019 Elsevier Ltd

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Biocompatibility; Cell proliferation; Chitosan; Cytotoxicity; Graphene oxide, Anti-bacterial activity; Antibacterial; Cytotoxicity effects; Hybrid structure; Nano hybrids; Network structures; Safety property; Structural characterization, Graphene
Subjects: فارماکولوژی QV > بیوتکنولوژی دارویی
> دانشکده داروسازی > فارماکولوژی QV > بیوتکنولوژی دارویی

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فارماکولوژی QV
> دانشکده داروسازی > فارماکولوژی QV

میکروب شناسی وایمنی شناسی QW
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 22 Sep 2019 06:27
Last Modified: 22 Sep 2019 06:27
URI: http://eprints.goums.ac.ir/id/eprint/10268

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