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Myeloid-derived suppressor cells and tumor: Current knowledge and future perspectives

Safari, E. and Ghorghanlu, S. and Ahmadi-khiavi, H. and Mehranfar, S. and Rezaei, R. and Motallebnezhad, M. (2019) Myeloid-derived suppressor cells and tumor: Current knowledge and future perspectives. Journal of Cellular Physiology, 234 (7). pp. 9966-9981.

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Abstract

The immunosuppressive features of tumor lesions participate not only as one of the major players inducing cancer progression but also a big challenge for effective immunotherapy. It has been found that immunosuppression associated with chronic inflammatory factors, such as growth factors, cytokines, and chemokines is generated by stroma and tumor cells. Chronic and exhaustive secretion of these mediators triggers the generation of myeloid-derived suppressor cells (MDSCs) demonstrating one of the key players engaged in tumor immunosuppression. In point of fact, direct cell-to-cell contact is a prerequisite for immunosuppressive functions of MDSCs. From the clinical perspective, the frequency of peripheral blood MDSCs is correlated with clinical stage and therapeutic response in various cancers. Furthermore, MDSCs are involved in chemoresistant settings. Altogether, it is a rational therapeutic approach to block the fierce cycle in which MDSCs are developed and infiltrated to favor cancer progression. In this review, we will summarize recent findings of MDSCs in tumor progression and discuss potential therapeutic strategies that could be evaluated in future clinical trials. © 2018 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: tumor marker, cell activation; cell expansion; cell maturation; human; myeloid-derived suppressor cell; neoplasm; nonhuman; priority journal; Review; transcription regulation; tumor growth; tumor microenvironment
Subjects: سیستم های خونی و لنفاوی WH
آسیب شناسی QZ
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 01 Jul 2019 06:17
Last Modified: 01 Jul 2019 06:17
URI: http://eprints.goums.ac.ir/id/eprint/10200

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