Golestan University of Medical Sciences Repository

Beneficial effects of Urtica dioica on scopolamine-induced memory impairment in rats: protection against acetylcholinesterase activity and neuronal oxidative damage

Ghasemi, S. and Moradzadeh, M. and Hosseini, M. and Beheshti, F. and Sadeghnia, H.R. (2019) Beneficial effects of Urtica dioica on scopolamine-induced memory impairment in rats: protection against acetylcholinesterase activity and neuronal oxidative damage. Drug and Chemical Toxicology, 42 (2). pp. 167-175.

Full text not available from this repository.

Abstract

This study was conducted to investigate protective effects of Urtica dioica extract on acetylcholinesterase (AChE) activity and the oxidative damage of brain tissues in scopolamine-induced memory impairment model. The rats were treated with (1) saline (control), (2) scopolamine, and (3�5) the plant extract (20, 50, or 100 mg/kg) before scopolamine. The traveled distance and the latency to find the platform in Morris water maze (MWM) by scopolamine-treated group were longer while the time spent in target quadrant was shorter than those of the control. Scopolamine decreased the latency to enter the dark in passive avoidance test. Besides, it also increased AChE activity and malondialdehyde (MDA) concentration in the hippocampal and cortical tissues while decreased thiols content and superoxide dismutase (SOD) and catalase (CAT) activities in the brain (p < 0.01�p <0.001). Treatment by the extract reversed all the effects of scopolamine (p < 0.05�p <0.001). According to the results of present study, the beneficial effects of U. dioica on memory can be attributed to its protective effects on oxidative damage of brain tissue and AChE activity. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: acetylcholinesterase; catalase; malonaldehyde; superoxide dismutase; Urtica dioica extract; acetylcholinesterase; malonaldehyde; neuroprotective agent; plant extract; scopolamine; superoxide dismutase, animal experiment; animal model; Article; brain cortex; brain tissue; colorimetry; controlled study; drug mechanism; enzyme activity; hippocampal tissue; hippocampus; male; maze test; Morris water maze test; neuroprotection; nonhuman; oxidative stress; passive avoidance; passive avoidance test; rat; scopolamine-induced cognitive defect; tissue homogenate; Urtica dioica; animal; brain chemistry; chemically induced; chemistry; drug effect; enzymology; memory disorder; metabolism; oxidative stress; Urtica dioica; Wistar rat, Acetylcholinesterase; Animals; Brain Chemistry; Cerebral Cortex; Hippocampus; Male; Malondialdehyde; Maze Learning; Memory Disorders; Neuroprotective Agents; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar; Scopolamine; Superoxide Dismutase; Urtica dioica
Subjects: سیستم عصبی WL
QS آناتومی انسان
QTفیزیولوژی
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 30 Jun 2019 09:24
Last Modified: 30 Jun 2019 09:24
URI: http://eprints.goums.ac.ir/id/eprint/10161

Actions (login required)

View Item View Item