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Therapeutic bacteria to combat cancer; current advances, challenges, and opportunities

Sedighi, M. and Zahedi Bialvaei, A. and Hamblin, M.R. and Ohadi, E. and Asadi, A. and Halajzadeh, M. and Lohrasbi, V. and Mohammadzadeh, N. and Amiriani, T. and Krutova, M. and Amini, A. and Kouhsari, E. (2019) Therapeutic bacteria to combat cancer; current advances, challenges, and opportunities. Cancer Medicine, 8 (6). pp. 3167-3181.

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Abstract

Successful treatment of cancer remains a challenge, due to the unique pathophysiology of solid tumors, and the predictable emergence of resistance. Traditional methods for cancer therapy including radiotherapy, chemotherapy, and immunotherapy all have their own limitations. A novel approach is bacteriotherapy, either used alone, or in combination with conventional methods, has shown a positive effect on regression of tumors and inhibition of metastasis. Bacteria-assisted tumor-targeted therapy used as therapeutic/gene/drug delivery vehicles has great promise in the treatment of tumors. The use of bacteria only, or in combination with conventional methods was found to be effective in some experimental models of cancer (tumor regression and increased survival rate). In this article, we reviewed the major advantages, challenges, and prospective directions for combinations of bacteria with conventional methods for tumor therapy. © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Item Type: Article
Additional Information: cited By 0
Subjects: آسیب شناسی QZ
میکروب شناسی وایمنی شناسی QW
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 30 Jun 2019 07:28
Last Modified: 30 Jun 2019 07:28
URI: http://eprints.goums.ac.ir/id/eprint/10139

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